Vall d'Hebron Research Institute (VHIR)
Neurovascular Research Laboratory
Neurovascular Research Laboratory has extensive experience in the study of Endothelial Progenitor Cells (EPCs) as mediators of tissue repair. We have recently demonstrated the therapeutic potential of EPCs secretome in a model of stroke and their remodelling actions. Exploring new therapeutic approaches, the group have started to work on nanotechnological platforms to improve angiogenesis and reurorepair treatments in collaboration with Anna Roig (ICMAB). Our know-how includes cell culturing techniques, in vitro and in vivo models of angiogenesis (migration, tubulogenesis, etc.), secretome production and in vivo stroke models. The team is composed by a neurologist, basic scientists and research technicians. Our Laboratory has previous experience in EU projects under the FP7: (EUSTROKE, MULTIPART and ERA-NET-NEURON).
Role in the project
Project Coordination, Pre-clinical stroke model, EPCs cultures and secretome production and in vivo/in vitro applications.
Dr. Anna Rosell
Dr. Rosell holds a Tenure Position at VHIR since February 2016. She finished her studies in biology in 2001 (Universitat Autonoma de Barcelona) and her PhD in Medicine by the UAB in 2005 with the work: “MMPs in brain parenchyma: role in tissue damage after human cerebral ischemia”. She spent 2 years as a postdoctoral fellow at the Neuroprotection Research Lab in the Massachusetts General Hospital (Boston, USA) in a world-leading laboratory recognised for their experimental studies in cerebral ischemia. She established a new neurorepair research program as principal investigator at the Neurovascular Research Laboratory at VHIR in 2010, when she was granted with the Miguel Servet position from the Spanish National Institute of Health and Research Agency (Instituto Carlos III) which supports researchers in biomedical institutions with a tenure-track appointment.
The focus of her research is the search of new therapies for stroke patients based on neurorepair strategies with specific emphasis on the role of angiogenesis and stem/progenitor cells treatments. Our know-how includes cell culturing techniques, in vitro and in vivo models of angiogenesis (migration, proliferation, tubulogenesis, etc.), secretome production and in vivo stroke models.
The neurovascular Research Lab. has participated in several EU granted projects from the FP7 (EUSTROKE, MULTIPART, PROTEA) and Dr. Rosell has been the PI of several research projects From the Instituto Carlos III (CP09, PI10, PI13, PI16).
She has over 90 publications with more than 2,800 citations and an h index=28. So far she has directed 5 doctoral thesis and 7 Master Thesis. She serves as reviewer for more than 20 journals of the neuroscience/ biomaterials fields and as projects’ reviewer for several national and International funding agencies.
Alba Grayston, MSc
Alba Grayston Morales is graduated in Biomedical Sciences by the Universitat Autònoma de Barcelona (UAB, 2016). She completed a master’s degree in Translational Biomedical Research at the Vall d’Hebron Research Institute – Universitat Autònoma de Barcelona (VHIR-UAB, 2017).
Miguel García-Gabilondo, BSc
Miguel is a Graduate in Biochemistry (Universitat de les Illes Balears, 2015) and a Superior Technician in Clinical Diagnostic Laboratory (2010). He has worked as a research assistant and laboratory technician in different laboratories before arriving to our group, where he is working mainly with cell cultures.
List of relevant publications
1) Anna Morancho, Feifei Ma,… Anna Rosell. Impaired vascular remodeling after endothelial progenitor cell transplantation in MMP9 deficient mice suffering cortical cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism. 2015 35(10):1547-51.
2) Carenza E, Jordan O,… Rosell A*, Roig A*. Encapsulation of VEGF165 in magnetic PLGA nanocapsules for potential local delivery and bioactivity into human brain endothelial cells. Journal of Materials Chemistry B. 2015;3, 2538-4.
3) Carenza E, Barcelo V,… Rosell A. In vitro angiogenic performance and in vivo brain targeting of magnetized endothelial progenitor cells for neurorepair therapies. Nanomedicine: NBM. 2014 Jan;10(1):225-34.
4) Anna Rosell*, Anna Morancho,… Joan Montaner. Treatment with Endothelial Progenitor Cells or their Secreted Factors Enhances Angiogenic and Neurogenic Responses after focal Cerebral Ischemia in Mice. PLoS One. 2013;8(9):e73244.
5) Anna Morancho, Mar Hernandez-Guillamon,… Anna Rosell. Cerebral Ischemia and Matrix Metalloproteinase-9 Modulate the Angiogenic Function of Endothelial Progenitor Cells. Journal of Cellular and Molecular Medicine. 2013;14(12):1543- 53.