Dr. Filip Jeleń

Pure Biologics Inc.

Brief CV

Filip Jelen graduated from the University of Wroclaw (2001) and received his PhD in biochemistry (2004) conducting research on thermodynamics of protein-protein interactions in a Department of Protein Engineering. As a postdoc (2007-2010) he joined Prof. F. Murad lab, Noble Prize laureate, in the Institute of Molecular Medicine (Houston, USA) to study cardiovascular diseases related signaling proteins. Currently holds an assistant Professor position at the Faculty of Biotechnology, University of Wroclaw. He has a broad experience in
biotechnology related businesses and is involved in many R&D projects associated with biologics and diagnostics development. Founder & CEO of one of the most innovative Life Science high tech companies in Poland: Pure Biologics (contract research and CMO specialized in custom recombinant protein and antibody production and analysis) and Captor Therapeutics (drug discovery in the field of oncology and inflammatory diseases).

Role in the project

Establishing the protocols for medium-scale EPC cultures and EPC-secretome production in GMP-like standards including quality testing; providing EPC-secretome material for other partners.

Team qualification in the field of proposal

Pure Biologics team includes several PhDs specialized in protein production, purification and characterization from different sources, including eukaryotic cells cultures. We have got experience in medium-scale production according to GLP and GMP standards, and we operate under PN-EN ISO 17025 norm - our competence is confirmed by over 7 years of successfull market presence and constant growth. Pure Biologics management has successfully coordinated and partnered in several publicly funded projects (including e.g. Eurostars EUREKA). The company has access to state-of-art facilities: Wroclaw Technology Park and Wroclaw Research Center EIT+, with the former including GMP-compliant clean room facilities designed especially for cell culture.

List of relevant publications

- Jurek PM., Zablocki K., Wasko U., Mazurek MP., Otlewski J., Jelen F. (2017) Anti- FGFR1 aptamer-tagged superparamagnetic conjugates for anti-cancer hyperthermia. Int J Nanomedicine 12, 2941-2950.

- Pala, K., Serwotka, A., Jelen, F., Jakimowicz, P., Otlewski, J. (2014) Tumorspecific  hyperthermia with aptamer-tagged superparamagnetic nanoparticles. Int J Nanomedicine; 9: 67–76

- Chauhan, S., Jelen, F., Sharina, I., Martin, E., (2012) The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase. Biochem J. 2012 Sep 15;446(3):445-53.

- Fernandes, H., Bujacz, A., Bujacz, G., Jelen, F., Jasinski, M., Kachlicki, P., Otlewski, J., Sikorski, MM., Jaskolski M. (2009) Cytokinin-induced structural adaptability of a Lupinus luteus PR-10 protein. FEBS J. Mar, 276(6):1596-609.

Total number of citations: 845; cumulative IF: 80.56; index-h: 11

Team members

Dr. Maciej Mazurek

Project Manager

R&D Department Director

Dr. Przemyslaw Jurek

Research Coordinator