The Neurovascular Research Laboratory (VHIR) has published a new article in collaboration with researchers of the Neuroprotection Research laboratory at Massachusetts General Hospital showing how Endothelial Progenitor Cells (EPCs) might participate in rescue from oxygen‐glucose deprivation by transferring mitochondria particles to damaged brain endothelial cells.
The investigation has been published at Stem Cells and one of the paper figures has illustrated the cover of the September’s issue. These findings suggest that EPCs may support brain endothelial energetics, barrier integrity and angiogenic function partly through extracellular mitochondrial transfer, and support their potential use in stroke repair.
Hayakawa K, Chan SJ, Mandeville ET, Park JH, Bruzzese M, Montaner J, Arai K, Rosell A, Lo EH. Protective Effects of Endothelial Progenitor Cell-Derived Extracellular Mitochondria in Brain Endothelium. Stem Cells. 2018 Sep;36(9):1404-1410. doi: 10.1002/stem.2856.